Common Alcohol Withdrawal Symptoms


Key Takeaways

  • Alcohol withdrawal symptoms can start within hours to a day or two after the last drink.
  • Symptoms are often at their worst 24 to 72 hours after stopping alcohol.
  • For severe symptoms, medical help is necessary as it can be life-threatening.

Alcohol withdrawal refers to the physical and mental effects a person experiences after stopping prolonged and heavy alcohol use. When you suddenly stop drinking, your body is deprived of the effects of alcohol and requires time to adjust to functioning without it. Depending on how long you have used alcohol and how much you typically drink, the severity of these symptoms can range from mild to severe.

This article discusses the causes, common symptoms, and different stages of alcohol withdrawal. It also discusses various treatment options for alcohol withdrawal and how you can get help.

Symptoms of Alcohol Withdrawal

The symptoms of alcohol withdrawal relate proportionately to the level of alcohol intake and the duration of the person’s recent drinking habit.

Not everyone who quits drinking alcohol experiences withdrawal symptoms, but many people who have been drinking for a long period of time, drink frequently, or drink heavily, will experience some withdrawal symptoms if they stop using alcohol suddenly.

There are several mild to moderate psychological and physical symptoms you might experience when you stop drinking.

Psychological Symptoms

  • Anxiety

  • Bad dreams

  • Depression

  • Difficulty thinking clearly

  • Fatigue

  • Feeling jumpy or nervous

  • Irritability or becoming excited easily

  • Rapid mood swings

  • Shakiness

Physical Symptoms

  • Clammy skin

  • Elevated blood pressure

  • Headache

  • Insomnia

  • Loss of appetite

  • Nausea and vomiting

  • Paleness

  • Rapid heart rate or palpitations

  • Sweating, especially the palms of your hands or your face

  • Tremor in your hands

Causes of Alcohol Withdrawal

Alcohol is a depressant, which means that it slows your brain. When a person drinks heavily, frequently, or for prolonged periods of time, their brain compensates for alcohol’s depressant effects by releasing more stimulating chemicals (compared to when a person does not drink). Overproduction becomes the brain’s new normal.

When a person stops drinking, their brain is still producing extra chemicals, which can potentially cause unpleasant alcohol withdrawal symptoms that are associated with overstimulation. The brain will readjust, but until it does, a person in withdrawal might feel unwell.

Timeline of Alcohol Withdrawal Symptoms

The severity of alcohol withdrawal is categorized into three stages. The symptoms of these stages range from mild to severe. Not all people progress through all of the stages of alcohol withdrawal.

Stage 1: Mild Withdrawal

Stage 1 is considered mild withdrawal. Mild withdrawal symptoms often begin within 6 to 12 hours after your last drink.

These first symptoms of withdrawal include:

Mild symptoms may appear similar to a hangover, but they last longer than 24 hours.

The exact timeline for alcohol withdrawal varies from person to person. It’s based on several factors, including how long, how much, and how regularly you have been drinking alcohol.

Stage 2: Moderate Withdrawal

Stage 2 is considered the moderate stage of withdrawal. This stage of alcohol withdrawal includes Stage 1 symptoms plus the following moderate symptoms:

  • Confusion
  • Excessive sweating
  • Fast heart rate (more than 100 beats per minute)
  • Fever
  • Increased systolic blood pressure
  • Mild tremor
  • Moderate anxiety
  • Rapid, shallow breathing

These symptoms generally appear 12 to 24 hours after your last drink. While these symptoms are more severe than Stage 1, they are not life-threatening.

Stage 3: Severe Withdrawal

Stage 3 is considered severe alcohol withdrawal. In addition to experiencing Stage 2 symptoms, those with severe alcohol withdrawal experience severe anxiety and moderate to severe tremors.

Complicated Withdrawal

If left untreated, withdrawal can progress to complicated alcohol withdrawal.

The symptoms of alcohol withdrawal delirium include withdrawal seizures that can occur between 8 and 28 hours after your last drink. Signs of an impending seizure include tremors, increased blood pressure, overactive reflexes, and high temperature and pulse. Having a history of seizures increases your risk for withdrawal seizures.

Alcohol withdrawal delirium (AWD), commonly known as delirium tremens (DT), is the most serious symptom of alcohol withdrawal. AWD usually lasts 48 to 72 hours.

DT can be life-threatening: About one in 20 people who develop the condition die from it. If you or a loved one has symptoms of DT, seek immediate emergency medical care.

The symptoms of delirium tremens include:

  • Agitation
  • Confusion (which can be severe)
  • Dangerous changes in blood pressure
  • Excessive sweating
  • Fever
  • Hallucinations
  • Heart arrhythmia (irregular heartbeat)
  • Rapid changes in mood
  • Seizures
  • Sensitivity to touch, light, and/or sound
  • Tremors

The symptoms of DT may get rapidly worse and can be fatal. A person with delirium tremens needs to be hospitalized until the symptoms can be controlled.

Duration of Alcohol Withdrawal

People who suddenly stop drinking and develop alcohol withdrawal symptoms often have two main questions: “Is this normal?” and “How long does it last?”

Withdrawal is different for everyone; there really is no “normal” and it can be hard to predict an individual person’s experience.

It’s typical for withdrawal symptoms to begin within hours to a day or two after you have your last drink. Symptoms are often at their worst around 24 to 72 hours after you stop drinking.

You’ll likely begin to feel better between five to seven days after you stop drinking, though some symptoms—like changes in sleep patterns, fatigue, and mood swings—can last for weeks or months.

Treatment of Alcohol Withdrawal

Alcohol withdrawal symptoms can be greatly reduced or even eliminated with proper medical care. There are specific treatments available for anyone who wants to stop drinking—even after long-term, chronic alcohol use.

Outpatient Treatment

Treatment varies depending on the severity of withdrawal symptoms. People experiencing mild to moderate alcohol withdrawal symptoms often receive outpatient care—meaning there is no extended time spent in a hospital or facility. It’s recommended, however, that they have someone stay with them who can help during recovery.

A healthcare provider may request daily visits during which they will likely run blood tests and monitor vital signs until symptoms stabilize.

Inpatient Treatment

Inpatient treatment, or staying at a hospital or care facility, may be necessary for someone with moderate to severe symptoms of alcohol withdrawal. Inpatient treatment allows healthcare professionals to monitor you for DT or hallucinations, monitor your vitals, and administer fluids or medicine intravenously if needed.

Ruling Out Other Conditions

A healthcare provider will also run tests to rule out other medical conditions that have similar symptoms of alcohol withdrawal or occur alongside withdrawal. These conditions include gastrointestinal bleeding, infection, intracranial hemorrhage (acute bleeding in the brain), and liver failure.

Counseling

Counseling is usually recommended for someone experiencing alcohol withdrawal. A counselor can advise on ways to cope with the mental and emotional aspects of withdrawal.

A counselor can help someone prepare for life after withdrawal and provide support as they navigate quitting drinking.

Medications for Alcohol Withdrawal Symptoms

A doctor may also prescribe a sedative drug, such as a benzodiazepine, to help reduce withdrawal symptoms such as restlessness or agitation. Benzodiazepines like Librium (chlordiazepoxide) and Ativan (lorazepam) may also help to prevent minor withdrawal symptoms from becoming more severe. Other drugs a healthcare provider might prescribe include anxiolytics , vitamins, and suboxone.

Getting Help for Alcohol Withdrawal

Once you have gone through withdrawal, you’ll also need a plan to remain alcohol-free. Start by talking to a healthcare provider about the treatment options for alcohol dependence.

There are many resources available for anyone who is ready to stop drinking for good, or who wants to reduce the harm alcohol is causing in their life by cutting down. As you continue to commit to long-term recovery, support group meetings like Alcoholics Anonymous (AA) or online support communities might be helpful.

Get Help Now

We’ve tried, tested, and written unbiased reviews of the best online therapy programs including Talkspace, Betterhelp, and Regain. Find out which option is the best for you.

Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Mirijello A, D’Angelo C, Ferrulli A, et al. Identification and management of alcohol withdrawal syndrome. Drugs. 2015;75(4):353-65. doi:10.1007/s40265-015-0358-1

  2. Sachdeva A, Choudhary M, Chandra M. Alcohol withdrawal syndrome: Benzodiazepines and beyond. J Clin Diagn Res. 2015;9(9):VE01-VE07. doi:10.7860/JCDR/2015/13407.6538

  3. Muncie HL Jr, Yasinian Y. Outpatient management of alcohol withdrawal syndrome. Am Fam Physician. 2013 Nov 1;88(9):589-595.

  4. Munda SK, Khess CRJ, Bhattacharjee D, Singh NK. Clinical manifestations of complicated alcohol withdrawal and uncomplicated alcohol withdrawal: A comparative study. Mental Health and Substance Use. 2013;7(3):243-255. doi:10.1080/17523281.2013.806950

  5. Kattimani S, Bharadwaj B. Clinical management of alcohol withdrawal: A systematic review. Ind Psychiatry J. 2013;22(2):100-108. doi:10.4103/0972-6748.132914

  6. Jesse S, Bråthen G, Ferrara M, et al. Alcohol withdrawal syndrome: Mechanisms, manifestations, and management. Acta Neurol Scand. 2016;135(1):4-16. doi:10.1111/ane.12671

  7. Grover S, Ghosh A. Delirium tremens: Assessment and management. J Clin Exp Hepatol. 2018;8(4):460-470. doi:10.1016/j.jceh.2018.04.012

  8. National Library of Medicine. Alcohol withdrawal.

  9. Hoffman RS, Weinhouse GL. Management of moderate and severe alcohol withdrawal syndromes. UpToDate.

Additional Reading

By Buddy T

Buddy T is a writer and founding member of the Online Al-Anon Outreach Committee with decades of experience writing about alcoholism. Because he is a member of a support group that stresses the importance of anonymity at the public level, he does not use his photograph or his real name on this website.


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Definition, Symptoms, Traits, Causes, Treatment


Key Takeaways

  • Cleithrophobia is the fear of being trapped, which can cause intense anxiety and panic attacks.
  • Therapy and medications like anti-anxiety drugs can help treat cleithrophobia.
  • Deep breathing and mindfulness can help calm anxiety in stressful situations.

Does the thought of being trapped in an enclosed space make you shudder? Does your heart start to race when you are locked in a small room? If the thought of being trapped in such situations triggers feelings of intense fear, you might have a type of phobia known as cleithrophobia.

Cleithrophobia, or the fear of being trapped, is a type of specific phobia. The root word for this phobia is from the Greek cleithro, which means to shut or close.

Many events might trigger cleithrophobia, including being locked in a bathroom or other small room. The condition can affect both children and adults and can lead to a range of disruptive and distressing symptoms.

Symptoms of Cleithrophobia

The symptoms of cleithrophobia are similar to those of other specific phobias. Common symptoms of cleithrophobia include:

  • Chest pain
  • Chills
  • Difficulty breathing
  • Dizziness
  • Fear of losing control
  • Nausea
  • Racing heartbeat
  • Shaking
  • Sweating

If you have this fear, you might experience a panic attack when you feel trapped. Crying, screaming, physically lashing out, freezing up, and attempting to run away are very common.

If you cannot leave the situation, you might start sweating profusely, feel your pulse rate begin to rise, and develop symptoms of physical illness. You will likely be unable to think of anything other than the need to escape.

How Is Cleithrophobia Diagnosed?

A doctor or mental health professional will ask questions about your symptoms to make a diagnosis. They may also take a medical history and conduct lab tests and a physical exam to rule out other conditions.

Cleithrophobia is not recognized as a distinct condition in the “Diagnostic and Statistical Manual of Mental Disorders” (DSM-5-TR). Instead, it would be classified as a form of specific phobia. To be diagnosed with a specific phobia:

  • The fear must create significant distress or disruption in a person’s life
  • The fear must be out of proportion to the actual danger
  • The person avoids the source of the fear or endures it only with extreme distress

These symptoms must be present for at least six months and must not be caused by another mental health or medical condition.

Cleithrophobia vs. Claustrophobia

Cleithrophobia is often confused with claustrophobia or the fear of enclosed spaces. While they share some similarities, there are several significant differences between the two conditions.

Claustrophobia may occur at any time. If you have claustrophobia, you might fully intend to enter a small space, such as a magnetic resonance imaging (MRI) chamber or a motion simulator, yet have a panic attack before or during the experience. The specific focus of the phobia itself is the small space.

Cleithrophobia is triggered by actual confinement in a small space. People with cleithrophobia are often entirely comfortable entering small areas they are free to leave. The specific focus of this phobia is being trapped, locked in, or otherwise unable to leave.

The difference between the two phobias is subtle but important. However, it can be nearly impossible to distinguish between them. Both phobias often cause anticipatory anxiety, in which you begin to panic long before the actual event occurs.

Cleithrophobia may mirror claustrophobia if you see even a slight risk of becoming trapped in the space. Likewise, claustrophobia often mirrors cleithrophobia in that many people with claustrophobia may feel trapped or locked in, even if they are actually free to leave.

The two phobias may even exist simultaneously. For these reasons, a trained mental health professional is needed to make the exact diagnosis. The treatment of the two conditions is similar.

What Causes Cleithrophobia?

Experts are not 100% clear on what causes people to develop a fear of being trapped. However, there are a number of factors believed to play a role in the development of cleithrophobia. These may include:

  • Genetics: Having family members with phobias or other anxiety disorders may increase your risk of developing a specific phobia, such as cleithrophobia.
  • Evolutionary factors: Some researchers suggest that evolutionary influences may play a role in the development of certain specific phobias.
  • Traumatic experiences: Traumatic events that lead to this phobia include getting trapped in a small tunnel or deep hole or being locked in a small space such as a closet, abandoned refrigerator, or car trunk.

In general, cleithrophobia is triggered by a lack of escape. Examples of common triggers include amusement park rides that utilize shoulder harnesses or other tight-fitting restraints, locked rooms, and MRI chambers.

Treatment for Cleithrophobia

Treatment for cleithrophobia depends on your needs and the severity of your symptoms. Options include medication, psychotherapy, and behavioral strategies.

  • Psychotherapy: Treatments for phobias often involve using cognitive-behavioral therapy (CBT) and related approaches, including exposure therapy and systematic desensitization. Such strategies help change the negative thoughts that contribute to fear and help you become gradually accustomed to the source of your fear to lessen its intensity.
  • Medication: There is no medication that has been specifically FDA-approved to treat cleithrophobia. However, your doctor may prescribe anti-anxiety medications to help you cope with feelings of anxiety. Examples of medications that might be prescribed include benzodiazepines and beta blockers.

How to Cope With Cleithrophobia

The anxiety and fear that phobias create can be really hard to deal with. You might even find it hard to function normally in your daily life. If you tend to have milder symptoms, you may find that self-help techniques can be very helpful.

Some strategies that can help ease feelings of anxiety and fear include:

Leaving an escape route, such as cracking the bathroom door or removing the locks from rooms in your home where you might feel trapped, may help you feel calmer in certain situations. But this is not always possible or practical. You may not be able to avoid locked doors in public places.

If you begin to panic, try using purposeful breathing or guided visualization to calm your anxiety. If you have a supportive friend or relative nearby, ask that person to speak calmly with you about light topics.

Some people find that the Stop! Technique helps curb anxiety, while others find that it does not work in the middle of a panic attack. This technique is a form of cognitive-behavioral therapy aimed at stopping racing thoughts or obsessive worrying. When thoughts of the fear arise, you yell Stop. At first, you may do so out loud, but eventually, you progress to doing so silently.

Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. American Psychiatric Association (APA). Diagnostic and Statistical Manual of Mental Disorders. 5th ed, text revision. Washington, D.C.; 2022.

  2. American Psychiatric Association (APA). Diagnostic and Statistical Manual of Mental Disorders. 5th ed, text revision. Washington, D.C.; 2022.

  3. Abend R, Gold AL, Britton JC, et al. Anticipatory threat responding: Associations with anxiety, development, and brain structure. Biol Psychiatry. 2020;87(10):916-925. doi:10.1016/j.biopsych.2019.11.006

  4. Eaton WW, Bienvenu OJ, Miloyan B. Specific phobias. Lancet Psychiatry. 2018;5(8):678-686. doi:10.1016/S2215-0366(18)30169-X

  5. Loken EK, Hettema JM, Aggen SH, Kendler KS. The structure of genetic and environmental risk factors for fears and phobias. Psychol Med. 2014;44(11):2375-2384. doi:10.1017/S0033291713003012

  6. Garcia R. Neurobiology of fear and specific phobias. Learn Mem. 2017;24(9):462-471. doi:10.1101/lm.044115.116

  7. Thng CEW, Lim-Ashworth NSJ, Poh BZQ, Lim CG. Recent developments in the intervention of specific phobia among adults: a rapid review. F1000Res. 2020;9:F1000 Faculty Rev-195. doi:10.12688/f1000research.20082.1

By Lisa Fritscher

Lisa Fritscher is a freelance writer and editor with a deep interest in phobias and other mental health topics.


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একাধিক নারীর সঙ্গে সম্পর্ক স্বামীর! বিয়ের ১৫ বছরে বড় সিদ্ধান্ত নিলেন স্বর্ণকমল দত্ত? #shorts



একাধিক নারীর সঙ্গে সম্পর্ক স্বামীর! বিয়ের ১৫ বছরে বড় সিদ্ধান্ত …

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What Is the CDT Blood Test for Alcohol?


Key Takeaways

  • A CDT blood test checks for levels of carbohydrate-deficient transferrin, which can reveal heavy alcohol use.
  • The CDT test is more dependable than self-reported drinking habits, which are not always honest.
  • Heavy drinkers are more likely to deny their drinking levels, so the CDT test helps provide a more accurate picture. 

There are a few different ways to learn about a person’s alcohol use. One is to ask them questions or use some screening questionnaire. In other cases, a blood test for alcohol can help healthcare providers learn more about current intoxication levels or regular alcohol consumption. The carbohydrate-deficient transferrin (CDT) blood test can provide information about a person’s past alcohol use and help diagnose an alcohol use disorder.

Tests for Alcohol Use

When gauging alcohol use in their patients, healthcare providers rely mainly on three methods:

  • Traditional brief screening
  • The blood alcohol concentration (BAC) test
  • The carbohydrate-deficient transferrin (CDT) test

The traditional brief alcohol screening isn’t as reliable as the other two methods because its accuracy depends solely on the patient being accurate and honest about how much they drink. While the BAC test measures the level of alcohol currently in the bloodstream, CDT testing uses biomarkers to detect a recent history of harmful levels of alcohol consumption.

The CDT test is a better indicator of binge drinking or daily heavy drinking (four or more drinks per day) than the other two tests. It can even help determine if a person with alcohol use disorder has had a relapse.

What Constitutes Heavy Drinking?

The Centers for Disease Control and Prevention (CDC) defines heavy drinking as consuming at least 15 drinks/week (for men) or eight drinks/week (for women). Notably, an estimated 90% of heavy drinkers don’t meet the diagnostic criteria for moderate or severe alcohol use disorder, a chronic brain disease that interferes with daily life.

What Is a CDT Blood Test?

As the name suggests, CDT blood testing measures the level of CDT in the bloodstream. Carbohydrate-deficient transferrin (CDT) is a substance that carries iron to the bone marrow, liver, and spleen.

When someone drinks heavily, the level of CDT in their body increases to a point at which it can be measured in a blood sample. Therefore, this increase is a biomarker of excessive alcohol use.

Biomarker

A biomarker (short for “biological marker”) is a molecule in the body that signals some condition or process. Healthcare providers and researchers use biomarkers in diagnosis, treatment, and testing—for example, to check how well a cancer treatment is working or to detect high cholesterol.

How the CDT Test Works

People who do not drink or drink only moderately have lower CDT levels in their blood than those who drink heavily. Some CDT tests use a cutoff of less than 1.7%. People who drink four or more drinks a day, at least five days a week, for two weeks before the test show significantly greater levels of CDT.

The CDT test is highly accurate in detecting heavy drinking. Similar to how an A1C test detects blood glucose levels over the previous 90 days, the CDT test detects heavy alcohol consumption over a long period. When a person stops drinking, CDT levels go back to normal after two to four weeks. Likewise, if they resume drinking, the levels once again increase after a few days.

When and Why CDT Is Tested

The CDT test gives a healthcare provider a far more reliable diagnostic tool than the traditional brief alcohol screening test, which relies on a patient’s honesty about their drinking habits.

People who don’t consume alcohol excessively tend to self-report accurately, but those who do are more likely to minimize their drinking levels. The greater the misuse, the more likely the person will deny heavy alcohol consumption.

Medical Conditions

Alcohol consumption is contraindicated for many medical conditions. People with diabetes, high blood pressure, hepatitis C, or liver disease should not drink heavily.

One study found that of 799 patients studied, 9% of subjects with diabetes and 15% of those with high blood pressure were consuming alcohol at harmful levels. When extrapolated to the population at large, these results could mean that millions of people with diabetes and hypertension are risking their health by drinking alcohol.

Using the CDT test to identify patients with diabetes, hypertension, and other conditions who are drinking too much could reduce medical complications and healthcare costs significantly.

Drug Interactions

Patients who take certain prescription and over-the-counter medications can experience harmful effects if they drink alcohol. Similarly, people who are being treated with opioid painkillers, sedatives, or sleep aids risk central nervous system depression should they drink alcohol heavily.

In a medical emergency, CDT testing could uncover alcohol use that’s reacting with medications and causing problems.

Recovery

CDT testing also can help healthcare providers monitor abstinence and relapse because the test is sensitive enough to detect increases and decreases in alcohol use.

Some psychotherapists and psychiatrists use the CDT test to determine a baseline level when they first begin treating a patient for alcohol use disorder. In the weeks and months that follow, they can use the CDT test to determine if the person is remaining sober or has had a relapse.

Accuracy of the CDT Blood Test for Alcohol

Researchers have conducted many studies on the effectiveness of using CDT testing to identify heavy alcohol consumption. Those studies find that the test is accurate but not foolproof.
Research has shown, for example, that transferrin mutations can cause false positive results, which can affect the diagnostic accuracy of the test.

False Negatives

In a small percentage of people, heavy alcohol consumption does not raise levels of CDT in the blood. A healthcare provider who suspects heavy drinking despite a negative CDT test may then turn to digital DNA methylation techniques, which rely on blood or saliva samples to detect heavy alcohol consumption.

False Positives

Biological factors such as genetic variants, female hormones, and end-stage liver disease can falsely increase CDT levels. The earliest CDT tests returned false positives due to these factors. Newer tests can identify genetic variants that can cause false positives and negatives, as well as patterns caused by liver disease related to heavy drinking.

Getting Help

It is crucial for your doctor or therapist to understand your alcohol consumption so they can determine which treatments may be most helpful for you. If your alcohol use is heavy and chronic, detoxing may put you at a higher risk for seizures and other symptoms of delirium tremens. Knowing this, your doctor may recommend medical monitoring during the detox process and prescribe medications that can minimize withdrawal symptoms and reduce alcohol cravings.

Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Solomons HD. Carbohydrate deficient transferrin and alcoholism. Germs. 2012;2(2):75-78. doi:10.11599/germs.2012.1015

  2. Liang SS, He Y, Huang ZG, Jia CY, Gan W. Evaluation of the diagnostic utility of carbohydrate-deficient transferrin in chronic alcoholism. Medicine (Baltimore). 2021;100(4):e24467. doi:10.1097/MD.0000000000024467

  3. Alcohol questions and answers. CDC.

  4. Fiorelli D, Romani L, Treglia M, et al. Carbohydrate-deficient transferrin (CDT) as a biomarker of alcohol abuse: A retrospective study of the Italian drinking trend among drivers from 2016 to 2022. Toxics. 2023;11(11):914. doi:10.3390/toxics11110914

  5. National Cancer Institute. Dictionary of cancer terms.

  6. Fagan KJ, Irvine KM, McWhinney BC, et al. Diagnostic sensitivity of carbohydrate deficient transferrin in heavy drinkers. BMC Gastroenterol. 2014;14:97. doi:10.1186/1471-230X-14-97

  7. Labcorp. Carbohydrate-deficient transferrin (CDT), adult.

  8. National Institute on Alcohol Abuse and Alcoholism(NIAAA). Harmful interactions.

  9. Zühlsdorf A, Said M, Seger C, et al. It is not always alcohol abuse—a transferrin variant impairing the CDT test. Alcohol and Alcoholism. 2016;51(2):148-153. doi:10.1093/alcalc/agv099

  10. van de Luitgaarden IAT, Schrieks IC, Kieneker LM, et al. Urinary ethyl glucuronide as measure of alcohol consumption and risk of cardiovascular disease: A population-based cohort study. J Am Heart Assoc. 2020;9(7):e014324. doi:10.1161/JAHA.119.014324

  11. Miller S, A Mills J, Long J, Philibert R. A comparison of the predictive power of DNA methylation with carbohydrate deficient transferrin for heavy alcohol consumption. Epigenetics. 2021;16(9):969-979. doi:10.1080/15592294.2020.1834918

  12. Fagan KJ, Irvine KM, McWhinney BC, et al. Diagnostic sensitivity of carbohydrate deficient transferrin in heavy drinkers. BMC Gastroenterol. 2014;14:97. doi:10.1186/1471-230X-14-97

By Buddy T

Buddy T is a writer and founding member of the Online Al-Anon Outreach Committee with decades of experience writing about alcoholism. Because he is a member of a support group that stresses the importance of anonymity at the public level, he does not use his photograph or his real name on this website.


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Kendra Cherry

How They Interact and Impact Behavior

Key Takeaways

  • The nervous system uses neurotransmitters and electrical signals to send information quickly, while the endocrine system uses hormones for slower, longer-lasting effects.
  • The hypothalamus is a crucial link between the nervous and endocrine systems, controlling the pituitary gland and hormone release. 

Human behavior, in all its complexity, is partly the product of interactions between two key physical components: the nervous and endocrine systems. The nervous system works with the endocrine system to detect and transmit signals from internal and external stimuli to maintain homeostasis in the body.

These two systems help regulate the electrical and chemical processes that relay information throughout and between the brain and body. These functions include metabolism, reproduction, emotion, and homeostasis.

How the Nervous and Endocrine Systems Work Together

These two important systems work together to perform a number of important functions, including:

  • Communication: The nervous system uses neurotransmitters and electrical impulses to send information quickly over short distances. The endocrine system relies on hormones released into the bloodstream, which is slower but longer-lasting.
  • Response coordination: The nervous system coordinates responses such as the reflexes and muscle contractions. The endocrine system is responsible for processes like metabolism and reproduction.
  • Stress: When faced with stress, the nervous system leads to fast, short-term actions. The endocrine system releases cortisol, affecting the body for longer periods. 

The Nervous System

Neurons—bundles of which make up nerves—are the building blocks of the body’s communication system. They’re organized into networks that allow signals to move between the brain and body. These networks, composed of about 86 billion neurons, comprise the nervous system.

The nervous system, in turn, has two parts: the central nervous system, which includes the brain and spinal cord, and the peripheral nervous system.

The Central Nervous System

The central nervous system (CNS) is made up of the brain and spinal cord. Together, they form, as the name suggests, the literal center of the body’s communication system.

The brain and spinal cord are vital to human life and function.

Protective barriers surround them, including bone (skull and spine) and membraneous tissue known as meninges. Additionally, the brain and spine are suspended in cerebrospinal fluid.

The CNS processes every sensation and thought that you experience. Receptors throughout the body gather sensory information and pass it on to the CNS. The CNS also sends messages to the rest of the body to control movement, actions, and responses to the environment.

The Peripheral Nervous System

The peripheral system (PNS) is composed of nerves that extend beyond the central nervous system. The neural networks that make up the PNS are actually bundles of axons from neuron cells. The nerve bundles range from relatively small to large enough for the human eye to see.

The PNS is further divided into two different systems: the somatic nervous system and the autonomic nervous system.

The Somatic Nervous System

The somatic nervous system transmits sensory communications and is responsible for voluntary movement and action. It is composed of sensory (afferent) neurons and motor (efferent) neurons.

Sensory neurons carry information from the nerves to the brain and spinal cord; motor neurons transmit information from the central nervous system to the muscle fibers.

The Autonomic Nervous System

The autonomic nervous system controls involuntary functions such as your heartbeat, respiration, digestion, and blood pressure. The system is also involved in emotional responses such as sweating and crying. The autonomic nervous system is subdivided into the sympathetic nervous system and parasympathetic nervous system.

The sympathetic nervous system controls the body’s response to an emergency. When the system is aroused, your heart and breathing rates increase, digestion slows or stops, your pupils dilate, and you begin to sweat.

The parasympathetic nervous system balances the sympathetic system. After a crisis or danger has passed, it helps calm your body by slowing heart and breathing rates, resuming digestion, contracting your pupils, and stopping sweating.

The Endocrine System

The endocrine system is composed of glands that secrete chemical messengers known as hormones, which the bloodstream carries to organs and tissues to regulate functions such as metabolism, digestion, blood pressure, and growth.

Some of the endocrine system’s most important glands are the pineal gland, hypothalamus, pituitary gland, thyroid, ovaries, and testes. Each works in specialized ways in specific areas.

Although the endocrine system is not directly linked to the nervous system, the two interact in a number of ways.

They’re linked by the hypothalamus, a tiny collection of nuclei at the base of the forebrain that controls an astonishing amount of human behavior, including emotional and stress responses. It’s also involved in basic drives such as:

Notably, the hypothalamus controls the pituitary gland, which in turn regulates the release of hormones from other glands in the endocrine system.

The endocrine system is not a part of the nervous system, but it is just as essential to communication throughout the body.

Although the nervous and endocrine systems are separate systems, they interact in important ways to influence human behavior. They work in tandem to help people respond to the world around them and to each other.

Frequently Asked Questions

  • Is the endocrine system part of the nervous system?

    Not directly, but it interacts with the nervous system in important ways. The hypothalamus connects the two and controls the pituitary gland, which in turn controls the release of hormones in the body.

  • How does the endocrine system interact with the nervous system?

    The endocrine and nervous systems communicate with each other through the hypothalamus, which controls basic drives such as hunger and thirst. The hypothalamus also regulates the pituitary gland, which governs the release of hormones by the body’s other glands.

  • How are the nervous and endocrine systems similar?

    The nervous and endocrine systems both interact with the hypothalamus, which controls communication between the two via chemical messengers. They’re both essential to the human body and work constantly to keep it functioning and responding to stimuli effectively.


Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Stangor C, Walinga J. Introduction to Psychology – 1st Canadian Edition.

  2. Zefferino R, Di Gioia S, Conese M. Molecular links between endocrine, nervous and immune system during chronic stress. Brain Behav. 2021;11(2):e01960. doi:10.1002/brb3.1960

  3. Herculano-Houzel S. The human brain in numbers: A linearly scaled-up primate brain. Front Hum Neurosci. 2009;3:31. DOI:10.3389/neuro.09.031.2009

  4. About The Brain and Spinal Cord. Neurological Surgery, University of Pittsburgh.

  5. The Central Nervous System. Department of Molecular and Cell Biology. University of California, Berkeley.

  6. Axons: The cable transmission of neurons. Queensland Brain Institute. The University of Queensland.

  7. Seligowski AV, Harnett NG, Merker JB, Ressler KJ. Nervous and endocrine system dysfunction in posttraumatic stress disorder: An overview and consideration of sex as a biological variable. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020;5(4):381-391. doi:10.1016/j.bpsc.2019.12.006

Kendra Cherry

By Kendra Cherry, MSEd

Kendra Cherry, MS, is a psychosocial rehabilitation specialist, psychology educator, and author of the “Everything Psychology Book.”


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What Is the CIWA Protocol for Alcohol Withdrawal?

Key Takeaways

  • The CIWA protocol helps healthcare professionals assess and manage alcohol withdrawal symptoms.
  • The protocol’s scoring system guides the intensity of treatment based on symptom severity. 

The CIWA protocol for alcohol withdrawal is a questionnaire that measures the severity of an individual’s alcohol withdrawal symptoms.

The goal of the CIWA protocol is to minimize the risk of complications and optimize the patient’s recovery. It is also known as the Clinical Institute Withdrawal Assessment for Alcohol scale.

History of the CIWA Protocol for Alcohol Withdrawal

The CIWA protocol was designed to standardize the care of patients with alcohol withdrawal and to improve outcomes. The original CIWA protocol included 30 items, but has since been reduced to include 10 in the revised version (CIWA-Ar).

More recently, the CIWA protocol has been shown to be an effective tool for managing alcohol withdrawal. A study published in Hospital Pharmacy in 2016 found that patients who were managed with the CIWA protocol had a reduced daily dose of diazepam without any apparent safety issues.

What Is the CIWA Protocol for Alcohol Withdrawal Used For?

The CIWA protocol is used to assess and manage the symptoms of alcohol withdrawal. It can be used in both inpatient and outpatient settings. Scores can be used to guide the intensity of treatment.

For example, a patient with a score of 16 or higher may require more intensive treatment—such as IV fluids or medications—than a patient with a score of 7 or lower. In addition to assessing the severity of symptoms, the CIWA protocol can also be used to monitor the patient’s response to treatment.

Below is a list of different uses for the CIWA protocol:

  • Inpatient detoxification: The CIWA protocol is often used in patients who are undergoing inpatient detoxification from alcohol. It is used to assess the severity of withdrawal symptoms and to guide the intensity of treatment.
  • Outpatient management: The CIWA protocol can also be used in outpatient settings, such as primary care or addiction counseling offices. It can be used to assess the severity of symptoms and to monitor the patient’s response to treatment.
  • Emergency department: The CIWA protocol is sometimes used in the emergency department to assess and manage alcohol withdrawal.
  • Research: The CIWA protocol is also used in research studies on alcohol withdrawal and its treatment.

How Do You Score the CIWA?

The CIWA protocol items are scored on a scale of 0-7, with higher scores indicating more severe symptoms. The final item regarding orientation to time and place is rated from 0-4. The CIWA score is based on the patient’s self-reported symptoms and observable signs. It takes two minutes to administer the assessment. Below are the total score ranges and their meaning:

  • 7 or below: minimal to mild withdrawal
  • 8-15: moderate withdrawal
  • 16 or more: severe withdrawal (impending delirium tremens)

Below are the categories covered by the 10 items:

  • Agitation
  • Anxiety
  • Auditory disturbances
  • Clouding of sensorium
  • Headache
  • Nausea/vomiting
  • Paroxysmal sweats
  • Tactile disturbances
  • Tremor
  • Visual disturbances

Scoring the CIWA protocol is simple and can be done by any healthcare professional who has been trained in its use.

The patient is first asked a question regarding the severity of their symptoms for each item where required. Next, the healthcare professional observes the patient for signs of withdrawal and rates the severity of each sign on a scale of 0-7. The total score is then calculated by adding up the scores for all 10 items.

What Are the Treatment Guidelines for the CIWA Protocol?

The treatment guidelines for the CIWA protocol are based on the severity of the patient’s symptoms.

  • Mild symptoms: Patients with mild symptoms may be treated with supportive care, such as IV fluids and close monitoring.
  • Moderate symptoms: Patients with moderate symptoms may be treated with more intensive interventions, such as IV medications or sedation.
  • Severe symptoms: Patients with severe symptoms may require intensive treatment in an inpatient setting, such as ICU care.

Impact of the CIWA Protocol for Alchohol Withdrawal

The CIWA protocol is a widely used tool for the assessment and treatment of alcohol withdrawal. It is simple to use and has been shown to be an effective way to manage the symptoms of withdrawal.

The impact of the protocol has shown to be positive, both in terms of the patient’s symptoms and the overall course of their treatment. Below are some specific examples of the positive impact of the CIWA protocol:

  • It can be used to guide the treatment of alcohol withdrawal, ensuring that patients receive the level of care they need.
  • It has been shown to be an effective way to manage the symptoms of alcohol withdrawal.
  • Implementation can lead to better outcomes for patients with alcohol withdrawal, including reduced need for medication.

Tips for Using the CIWA Protocol

Here are some tips to keep in mind when using the CIWA protocol for alcohol withdrawal:

  • Start the CIWA protocol as soon as the patient arrives at the facility.
  • Repeat the assessment at regular intervals until the patient’s symptoms are under control.
  • Have a trained healthcare professional implement the CIWA protocol.
  • Follow the treatment guidelines based on the severity of the patient’s symptoms.

Potential Pitfalls of the Protocol

There are some potential pitfalls to be aware of when using the CIWA protocol for alcohol withdrawal. These include the following:

  • Failure to start the CIWA protocol in a timely manner
  • Inadequate training resulting in incorrectly scoring the CIWA
  • Not repeating the assessment frequently enough
  • Not following the treatment guidelines based on the severity of the patient’s symptoms
Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. American Society of Addiction Medicine. Clinical Institute Withdrawal Assessment

    of Alcohol Scale, Revised (CIWA-Ar).

  2. Eberly ME, Lockwood AG, Lockwood S, Davis KW. Outcomes After Implementation of an Alcohol Withdrawal Protocol at a Single Institution. Hosp Pharm. 2016;51(9):752-758. doi:10.1310/hpj5109-752

  3. Sullivan JT, Sykora K, Schneiderman J, Naranjo CA, Sellers EM. Assessment of alcohol withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA-Ar). Br J Addict. 1989;84(11):1353-1357. doi:10.1111/j.1360-0443.1989.tb00737.x

  4. Steel TL, Giovanni SP, Katsandres SC, et al. Should the CIWA-Ar be the standard monitoring strategy for alcohol withdrawal syndrome in the intensive care unit?. Addict Sci Clin Pract. 2021;16(1):21. Published 2021 Mar 24. doi:10.1186/s13722-021-00226-w

  5. Bacon O, Robert S, VandenBerg A. Evaluating nursing satisfaction and utilization of the Clinical Institute Withdrawal Assessment for Alcohol, revised version (CIWA-Ar). Ment Health Clin. 2016;6(3):114-119. Published 2016 May 6. doi:10.9740/mhc.2016.05.114

Arlin Cuncic

By Arlin Cuncic, MA

Arlin Cuncic, MA, is the author of The Anxiety Workbook and founder of the website About Social Anxiety. She has a Master’s degree in clinical psychology.


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Importance + How to Improve It


Key Takeaways

  • Being open and honest with your partner helps you share worries and handle conflicts better.
  • Good communication means not just talking but also listening and understanding your partner’s feelings. 

Communication is vital for healthy relationships. Being able to talk openly and honestly with the people in your life allows you to share, learn, respond, and forge lasting bonds. This is a vital part of any relationship, including those with friends and family, but it can be particularly important in romantic relationships. 

What Kind of Communicator Are You?

Our fast and free communication styles quiz can help give you some insight into how you interact with others and what it could mean for your interpersonal relationships, both at work and at home.


This communication styles quiz was reviewed by Ivy Kwong, LMFT.

Benefits of Communication in Relationships

According to Dr. John Gottman, a clinical psychologist and founder of the Gottman Institute, a couple’s communication pattern can often predict how successful a relationship will be. Good communication can help enhance your relationship in a variety of ways:

Less Rumination

Communication in relationships can minimize rumination. Instead of stewing over negative feelings, good communication allows people to discuss their concerns and resolve them in a more positive, effective way.

Greater Intimacy

Good communication in relationships also fosters intimacy. Forming a close emotional connection with another person requires a mutual give-and-take when it comes to sharing things about yourself and listening to the other person.

This reciprocal self-disclosure means talking about your experiences, beliefs, values, opinions, and expectations. In order to do this, you both need to possess communication skills that foster this connection and allow it to grow and deepen with time. 

Less Conflict

Communication in relationships reduces and resolves conflict. Every relationship is bound to experience conflict from time to time.

When you are able to talk about your problems in an open and honest way, however, you can resolve arguments and disagreements more readily.

Rather than getting caught up in a cycle of misunderstandings, hurt feelings, and emotional strife, you can address your problems and take steps to improve your relationship.

Communication Doesn’t Solve Everything

While the common assumption has long been that if you want to improve your relationship, you should start by improving your communication, some research has suggested that the answer might not be so simple. 

A study published in the Journal of Marriage and Family found that while there is certainly a connection between communication and relationship satisfaction, good communication alone doesn’t definitively predict how happy you’ll be in your relationships.

Other Factors Play a Role

Other factors—including how much interaction a couple has, the personality characteristics of each partner, and stress—all play a part in determining how satisfied people feel in their relationship.

Another study found that positive communication did not have a strong connection with relationship satisfaction over time. However, couples that reported less negative communication than usual and reported feeling more satisfied with their relationship than they usually did.

So while research suggests that communicating well isn’t a guarantee for a happy relationship, there is plenty of research indicating that good communication skills enhance relationships and well-being in a number of ways.

Effective communication is one way to foster a positive, supportive relationship with your partner.

When you actively listen and respond to your partner (and they do the same for you), both of you are more likely to feel valued and cared for. 

For example, one study found that when people feel that their partner values them, they are more likely to sleep better. And ultimately, feeling more valued, positive, and happy in your relationships can have a beneficial impact on your overall well-being. 

Recap

Communication is just one part of a good relationship. Research suggests that people who are happy in their relationships are more likely to communicate well with one another. 

Signs of Great Communication in Relationships

So what do experts mean when they talk about “good communication?” Are you and your partner both on the same page or are there signs that might indicate a problem in how you relate to one another? 

First, it is important to think about what we mean by communication. On the surface, it involves the words that people use to convey information to one another.

But it can also involve other ways of transmitting information including tone of voice, body language, and other forms of nonverbal communication. In many cases, what you don’t say can mean just as much if not more than what you do say.

Some of the hallmarks of effective communication in relationships include:

  • Active listening: Active listening involves being engaged in the conversation, listening attentively, and reflecting back on what people have said. It also involves asking for clarification when needed and avoiding making judgments. 
  • Not personalizing issues: When communicating in relationships, people who are good at it avoid personalizing their partner’s actions. Instead, they focus on the situation and how things can be resolved.
  • Using “I feel” statements: I-statements can be helpful in interpersonal conflicts. Instead of saying, “You never clean up after yourself,” try using an I-statement like, “I feel uncomfortable when there is clutter accumulating around the house.”
  • Kindness: Kindness is important because it makes people feel cared for and understood.
  • Being present: When talking with your partner, it is important to be fully present in the moment. Getting distracted by outside sources–including electronic distractions such as your phone–can lead to a lack of communication and a poor connection.
  • Showing acceptance: Healthy communication is about accepting and validating the other person, even if you might not agree with them. When you communicate well with your partner, you’re able to recognize that people have a right to feel their feelings even if those emotions and reactions are different from your own.

Recap

Communicating well in relationships involves actively listening, avoiding judgments, and practicing kindness instead of trying to win the argument.

Signs of Poor Communication in Relationships

Some signs that your relationship is being negatively affected by communication problems include:

  • Assuming that you know what your partner thinks or feels
  • Constantly criticizing one another
  • Engaging in passive-aggressive behaviors
  • Feeling like you can’t really talk to your partner
  • Getting defensive when your partner tries to talk to you
  • Giving each other the silent treatment
  • Having the same arguments over and over without reaching a resolution
  • Refusing to compromise or listen to the other person’s perspective
  • Stonewalling in order to avoid problems or conversations

It is also important to learn to recognize some of the more subtle signs of poor communication. This can include avoiding arguments for the sake of keeping the peace.

If you never disagree, it means that one of you is hiding what you really feel or think just to avoid a fight. This deprives you both of experiencing authentic, open, and honest discussions.

Withholding issues can be another common communication problem in relationships. Instead of having tough conversations with your partner, you might avoid the issue and then end up dumping all of your anger, irritation, worries, or problems on the other people in your life. 

For example, when you don’t tell your partner you are upset, you might end up ranting to your friend about your frustrations. While this might provide you with an emotional outlet, it doesn’t do anything to resolve the problem. And it might result in passive-aggressive actions designed to “punish” your partner for not being able to read your mind.

Recap

Criticisms, defensiveness, silence, and feeling misunderstood are just a few signs of communication problems in a relationship. And a lack of arguing isn’t necessarily a sign that you’re communicating well. Instead, it may mean you are holding back in order to avoid conflict.

5 Ways to Improve Communication in Relationships

If you think that poor communication is having a negative impact on your relationship, there are strategies that can help you improve your connection.

Consider Your Attachment Style

Think about how your attachment style might affect your communication patterns. Attachment styles are your characteristic patterns of behavior in relationships. Your early attachment style, which emerges in childhood based on relationships with caregivers, can continue to affect how you behave and respond in adult romantic relationships.

If you have an insecure attachment style, you may be more likely to engage in communication patterns that can be seen as anxious or avoidant. Recognizing how your attachment style affects how you interact with your partner (and how your partner’s style affects how they interact with you) can give you clues into what you might need to work on.

Recap

If you or your partner have an insecure attachment style, it can have an impact on how you communicate and interact with your partner. Knowing your style and being aware of how it may manifest as anxious or avoidant behavior can help you find ways to overcome less effective communication patterns.

Be Fully Present

In order to make sure that both of you are listening and understanding, minimize distractions and focus on being fully present when you are communicating. This might involve setting aside time each day to really focus on one another and talk about the events of the day and any concerns you may have. 

Limiting your device use at certain times of day, such as during meals or at bedtime, can be a great way to focus on your partner without having your attention pulled in different directions.

Use “I” Statements

Sometimes the way that you talk to each other can play a major role in communication problems. If you are both focusing on arguing facts without talking about feelings, arguments can quickly turn into debates over who is “right” or who gets the last word.

Examples of “I” Statements

“I” statements are focused on what you are feeling instead of your partner’s behavior. For example, instead of saying, “You are never on time,” you might say “I get worried when you don’t arrive on time.”

Using this type of statement can help conversations seem less accusatory or blaming and instead help you and your partner focus on the emotions behind some of the issues you are concerned about.

Avoid Negative Communication Patterns

When you are tempted to engage in behavior like ignoring your partner, using passive-aggressive actions, or yelling, consider how your actions will negatively affect your relationship.

It isn’t always easy to change these patterns, since many of them formed in childhood, but becoming more aware of them can help you start to replace these destructive behaviors with healthier, more positive habits.

Focus on Your Relationship

While good communication is important, research suggests that it is just one of many factors that impact the success, duration, and satisfaction in relationships. 

In fact, research seems to suggest that your satisfaction with your relationship might predict how well you and your partner communicate.

The more satisfied people are in their relationship, the more likely they are to openly talk about their thoughts, feelings, concerns, and problems with one another.

Recap

If you want to improve your communication, focusing on improving your relationship overall can play an important role.

When to Get Help

There are many steps you can take to improve the communication in your relationship on your own, but there may be times that you feel like professional help might be needed. Couples therapy can be a great way to address communication problems that might be holding your relationship back. 

A therapist can help identify unhelpful communication patterns, develop new coping techniques, and practice talking to one another in more effective ways. They can also address any underlying resentments or other mental health issues that might be having a detrimental impact on your relationship.

Always remember that the goal of communicating is to understand one another. It isn’t about sweeping problems under the rug in order to prevent all conflict. Instead, focus on listening to understand and responding with empathy and care. If you and your partner are struggling with communication issues, consider talking to a therapist for advice and tips on how to cope.


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