What Happens If You Miss One Dose of Antidepressants?


Key Takeaways

  • If you miss a single dose of antidepressants, you may experience mild, short-term symptoms like nausea and dizziness due to a drop in medication levels in your body.
  • Take it as soon as you remember, unless it’s close to the time of your next dose; then just skip it and take your next dose as scheduled to avoid doubling up.
  • Taking your medication consistently and talking to your doctor before making any medication changes can help you avoid uncomfortable discontinuation symptoms.

Missing a dose of your antidepressant can lead to flu-like symptoms such as upset stomach, achiness, and dizziness. These temporary symptoms are known as antidepressant discontinuation syndrome (ADS), which happens when your body reacts to a sudden dip in the medication levels. While skipping one pill usually isn’t harmful, some people may feel the effects more strongly than others.

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How Missing One Dose of Antidepressants Can Affect You

Missing a dose of Zoloft or another antidepressant may be enough to trigger symptoms of discontinuation syndrome in some people. For many people, discontinuation syndrome symptoms may be quite mild, but others may find them particularly difficult to cope with. Some of the most common symptoms include the following.

  • Agitation
  • Anxiety
  • Blurred vision
  • Chills
  • Dizziness
  • Fatigue
  • Headache
  • Insomnia
  • Irritability
  • Muscle pain
  • Nausea
  • Runny nose
  • Sweating
  • Tingling sensations
  • Tremor
  • Vivid dreams

Less common symptoms are:

  • Electric shock sensations
  • Hallucinations
  • Hypertension
  • Lack of coordination

How long do these symptoms last?

Rest assured that these symptoms:

  • Generally tend to be mild
  • Usually go away within one to two weeks
  • Are easily treatable if they become moderate or severe

Why You Might Have These Symptoms After Missing a Dose

There are several different causes of discontinuation syndrome. Here is an overview of the most common causes of your symptoms.

  • Suddenly stopping your antidepressant: If you’ve been taking an antidepressant for a month or more and you suddenly quit taking it, you’re far more likely to have discontinuation symptoms than if you had tapered off slowly. It may take one to four days before you notice symptoms. For example, missing a Lexapro dose (or a few doses) might cause you to begin experiencing symptoms over the next few days.
  • Tapering off of your antidepressant too quickly: Especially if you’ve been taking a high dose or you’ve been on an antidepressant for an extended period of time, a slow and gradual tapering schedule is necessary to prevent discontinuation symptoms.
  • Missing or skipping a dose or two of your antidepressant: It’s estimated that up to 70% of people who take antidepressants skip doses here and there. However, doing this increases your risk of developing discontinuation symptoms, especially if you’re taking an antidepressant with a short half-life. These types are eliminated from your body so rapidly that discontinuation symptoms may appear fairly soon after a missed dose, sometimes within hours.
  • Switching to a different formulation: Though this isn’t common, if you’re going from a brand-name antidepressant to a generic or from one generic to another made by a different company, the formulation may be different enough to experience discontinuation symptoms.

Suddenly discontinuing or significantly and quickly lowering your dose of any type of antidepressant puts you at risk for discontinuation symptoms.

The most common culprit seems to be immediate-release Effexor (venlafaxine) because it has a half-life as short as three to five hours, and it’s also the most likely antidepressant to cause these symptoms when you miss a dose or take it late.

Other more common culprits of discontinuation syndrome include:

  • Paxil (paroxetine)
  • Pristiq (desvenlafaxine)
  • Zoloft (sertraline)
  • Elavil (amitriptyline)
  • Tofranil (imipramine)
  • All monoamine oxidase inhibitors (MAOIs)

How common is it to have symptoms?

Research suggests that around 70% of people who are prescribed antidepressants miss doses occasionally. Around 40% of those who suddenly stop taking their medication experience symptoms of antidepressant discontinuation syndrome.

How to Feel Better After You Miss a Dose

Treatment for discontinuation syndrome may involve restarting the medication and then slowly tapering. In some cases, however, people may be unwilling or unable to restart the medication, particularly if they experienced severe or significant side effects. 

Discontinue syndrome is less frequent and severe when taking Prozac (fluoxetine), so your doctor may recommend switching to that drug before you stop taking your medication.

If restarting and tapering the medication is not an option, withdrawal symptoms will typically resolve within one to two weeks. The most severe symptoms often begin to improve within one to three days. During this time, supportive self-care can help people manage symptoms until they recover.

How to Stop It From Happening Again

So how can you prevent discontinuation symptoms from happening?

  • First, if you do miss a dose of your antidepressant, don’t panic. It happens to the best of us.
  • Go ahead and take it as soon as you remember, unless it’s close to time for your next dose.
  • In that case, don’t double up; just skip the missed dose and take your next dose as usual.

Here are some other ways to prevent discontinuation syndrome.

Take Medicine on Time

The best way to avoid having these symptoms is to be very careful with properly timing your medication dose. Taking your medication as prescribed also makes it as effective as possible in treating your depression symptoms.

One good way to make sure you take your medicine at the right time is to set alarms in your calendar or clock on your smartphone or computer.

If you’re not a techie, consider using an old-fashioned alarm clock, writing yourself notes, leaving your medicine out where you can see it, setting an alarm on your watch, and/or getting a pill box for each day of the week.

Think About Switching

If you’re finding taking your medication on time difficult to manage, consider asking your doctor about trying a different antidepressant with a longer half-life or an extended-release formula so you don’t have to take it as often. 

For instance, Prozac (fluoxetine) has a half-life of four to six days, so it takes longer to completely clear out of your body than other antidepressants. This means that the likelihood of having discontinuation symptoms if you miss a dose is pretty low.

Missing a dose of Prozac would result in fewer symptoms than missing a dose of Zoloft or Effexor.

Talk to Your Doctor Before Stopping

If you ever need to stop taking your antidepressant altogether, you should always consult with your doctor first. 

Don’t ever stop your antidepressant without your doctor’s knowledge.

Depending on what you’re taking, how long you’ve been taking it, and the dosage, they can help you avoid discontinuation syndrome by creating a plan to gradually and slowly taper you off your medication if needed.

Does This Mean I’m Addicted to Antidepressants?

Discontinuation syndrome is quite common. Although many experts refer to this phenomenon as withdrawal, experiencing antidepressant discontinuation syndrome doesn’t mean that you’re addicted. 

Antidepressants are rarely habit-forming and don’t create the cravings, euphoric effects, tolerance, or drug-seeking behavior that are seen with drugs of abuse. Another difference is that symptoms of discontinuation syndrome are generally milder and last for less time than symptoms of illicit drug withdrawal.

Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Gabriel M, Sharma V. Antidepressant discontinuation syndrome. CMAJ. 2017;189(21):E747. doi:10.1503/cmaj.160991

  2. Bhat V, Kennedy SH. Recognition and management of antidepressant discontinuation syndrome. J Psychiatry Neurosci. 2017;42(4):E7-E8. doi:10.1503/jpn.170022

  3. Warner CH, Bobo W, Warner C, Reid S, Rachal J. Antidepressant discontinuation syndrome. Am Fam Physician. 2006;74(3):449-456.

  4. Henssler J, Schmidt Y, Schmidt U, Schwarzer G, Bschor T, Baethge C. Incidence of antidepressant discontinuation symptoms: a systematic review and meta-analysisThe Lancet Psychiatry. 2024;11(7):526-535. doi:10.1016/S2215-0366(24)00133-0

  5. Bhat V, Kennedy SH. Recognition and management of antidepressant discontinuation syndromeJ Psychiatry Neurosci. 2017;42(4):E7-E8. doi:10.1503/jpn.170022

  6. Wilson E, Lader M. A review of the management of antidepressant discontinuation symptoms. Ther Adv Psychopharmacol. 2015;5(6):357-368. doi:10.1177/2045125315612334

Additional Reading

By Nancy Schimelpfening

Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be.  


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Rachael Green

Signs, Causes, and How to Cope

Key Takeaways

  • Disorganized attachment often involves a strong desire for closeness but also a fear of it, leading to push-pull behaviors in relationships.
  • This attachment style usually develops in response to early trauma, fear, or inconsistent caregiving.
  • Recognizing these patterns can help individuals build healthier, more secure relationships over time.

Disorganized attachment, also known as fearful-avoidant attachment, often involves wanting to be loved but feeling unsafe when it is offered. People with this style may alternate between seeking closeness and suddenly pulling away or reacting with anger.

It’s the rarest and most extreme form of insecure attachment and usually stems from specific types of trauma early in life. Recognizing these patterns is the first step toward forming a healthier, more secure relationship.

Xavier Lorenzo / Getty Images


What Does Disorganized Attachment Look Like?

Disorganized attachment is characterized by an extreme desire to be in an intimate relationship while simultaneously being intensely afraid of actually being in such a relationship. These conflicting emotions and behaviors that go with them distinguish it from a different anxious or avoidant attachment style.

  • Someone with an anxious attachment style is so intent on being in a secure relationship that they’re able to overlook many red flags and do everything they can to stay in the relationship, even when it’s unhealthy.
  • Someone with an avoidant attachment style is so afraid of intimacy that they push people away or avoid relationships at all costs.
  • Someone with a disorganized attachment style does both. They crave intimacy and are viscerally terrified of it at the same time. As a result, they may show both anxious and avoidant behaviors, which can make it easy to misidentify the attachment style. It’s the back-and-forth between the two extremes that is the telltale sign.

Some signs you could look for in your own thoughts and behavior if you suspect you might have a disorganized attachment style include:

  • A strong need for closeness and connection
  • Feeling unlovable or unworthy
  • Finding it painfully difficult to open up or be vulnerable with another person
  • Struggling to believe your partner when they say they love you or support you
  • Feeling uncomfortable or distrustful of your partner’s supportive actions or attempts to connect with you
  • Constantly looking for signs of rejection or betrayal when you’re in a relationship

Take the Attachment Style Quiz

If you’re unsure about your attachment style, this fast and free quiz can help you identify what your thoughts and behaviors may say about your attachment.


This attachment styles quiz was reviewed by David Susman, PhD.

Why Does Disorganized Attachment Develop?

Disorganized attachment is believed to be a result of extreme childhood trauma. While trauma can take many forms, this style is thought to stem specifically from traumatic situations where an attachment figure—a person a child feels dependent on for survival—becomes a source of fear rather than security.

A child who experienced verbal, physical, or sexual abuse, for example, may develop disorganized attachment, as would a child who witnessed an attachment figure commit a violent or abusive act against someone else. Neglect or abandonment can also be traumatic, but is more likely to result in anxious or avoidant attachment styles.

The difference between the type of attachment styles developed has nothing to do with whose experiences were more or less traumatizing, but rather how the trauma shaped the person’s bond with an attachment figure.

In the case of disorganized attachment, an attachment figure who abused the child or other people in front of the child becomes a source of fear. This person, who was supposed to be a source of safety, becomes a threat that the child has to learn to avoid in order to survive.

Despite that fear, the child is often still dependent on this attachment figure. Feeling trapped in this environment, the child does their best to behave in ways to protect themselves from abuse. But because abuse doesn’t follow any rational pattern, they never know what to expect or what the right way to behave would be.

Over time, they get used to close relationships feeling unsafe and unstable. So even though they crave the love and safety of an intimate relationship, they don’t know how to feel safe and loved in one.

How It Shows Up in Relationships

When a person with a disorganized attachment style approaches any type of intimacy or close bond with another person, they’re filled with an overwhelming and conflicting sense of longing and dread. This can cause a lot of issues in a relationship, including:

  • Mixed signals, such as switching between being very clingy to very distant at the flip of a switch
  • A lack of trust that can look like being overly suspicious or jumping to conclusions based on little to no evidence
  • A tendency to shut down or go numb during arguments
  • Sabotaging relationships, often by finding an excuse to end it or by doing something to make the other person end it
  • Choosing unsuitable partners, such as someone who is potentially abusive or controlling
  • Seeking out or creating unhealthy relationship dynamics, like picking fights or intentionally hurting the other person

Healing Disorganized Attachment in Relationships

As much as it may feel impossible to trust others and feel safe again after trauma, it’s possible to break the pattern and become capable of being in a secure, healthy relationship. Here are some of the most important steps you can take.

Talk to a Therapist

While it’s definitely possible to have a healthy relationship with a disorganized attachment style, it’s often necessary to heal the underlying trauma to do so. It can be painful to confront that past, and you may not even know where or how to start. Professional training and insight from a therapist can help you navigate this painful and overwhelming process safely.

Start Journaling

If you’re not ready to see a therapist or are seeing one but you’re not ready to explore your trauma with them yet, a gentler first step can be expressing it on your own.

  • You might start by describing the plain facts of your traumatic past: the who, what, when, and where.
  • Then, sit down each night to write about your day and reflect on any events or thoughts that might be related to your disorganized attachment style or trauma.

Keeping a journal is a helpful starting point because it gives you control of the process. It’s a tangible object that you can open up when you’re ready to reflect on your past and put away when you need a break. Regaining some sense of control over the experience this way can eventually make the task of opening up to a therapist less daunting.

Practice Self-Compassion

Disorganized attachment tends to come with a lot of negative self-talk. You might feel like you’re unlovable or that you don’t deserve a healthy, loving relationship. You can end up projecting this negativity onto your partner, assuming they also must think you’re unlovable.

One way to start healing is to counter those negative thoughts with compassion. Make the following habits part of your routine:

  • Do something to take care of your physical well-being. Take a moment to recognize something your body needs and do that for yourself, like taking a walk or eating something healthy.
  • Perform a small act of kindness for yourself every day. Do something that makes your day just a bit more pleasant, like going to your favorite beach or park after work or waking up ten minutes early to eat breakfast without rushing.
  • Notice your strengths and the things you do right. You might feel like there are none for you to notice, but you can start with smaller things that may feel silly to acknowledge. Maybe you’re good at remembering to feed your dog or you make the best grilled cheese sandwich, for example.
  • Practice compassion toward others. Research shows that engaging in little acts of kindness can increase a person’s sense of self-worth and self-esteem, so try volunteering at a shelter or helping a neighbor unload their groceries.
Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Steven Rholes W, Paetzold RL, Kohn JL. Disorganized attachment mediates the link from early trauma to externalizing behavior in adult relationships. Personality and Individual Differences. 2016;90:61-65. doi:10.1016/j.paid.2015.10.043

  2. Camerman E, Scheveneels S, Bosmans G. In safe hands: Attachment figures’ safety properties and the link with attachment style. Behaviour Research and Therapy. 2023;163:104274. doi:10.1016/j.brat.2023.104274

  3. Cassidy J, Mohr JJ. Unsolvable fear, trauma, and psychopathology: Theory, research, and clinical considerations related to disorganized attachment across the life span. Clinical Psychology: Science and Practice. 2001;8(3):275-298. doi:10.1093/clipsy.8.3.275

  4. Beeney JE, Wright AGC, Stepp SD, et al. Disorganized attachment and personality functioning in adults: A latent class analysisPersonal Disord. 2017;8(3):206-216. doi:10.1037/per0000184

  5. Klein N. Prosocial behavior increases perceptions of meaning in life. The Journal of Positive Psychology. 2017;12(4):354-361. doi:10.1080/17439760.2016.1209541

Rachael Green

By Rachael Green

Rachael is a New York-based writer who writes for Verywell Mind, where she leverages her decades of personal experience with and research on mental illness—particularly ADHD and depression—to help readers better understand how their mind works and how to manage their mental health.


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