What Is Drug Toxicity and What Are the Signs?


Toxicity refers to how poisonous or harmful a substance can be. In pharmacology, drug toxicity occurs when a person has accumulated too much of a prescription drug in their bloodstream, leading to negative effects.

Drug toxicity is formally defined as “a diverse array of adverse effects which are brought about through drug use at either therapeutic or non-therapeutic doses.” Whether because of a drug overdose,

Drug Toxicity vs. Drug Overdose

Drug toxicity and drug overdose are often confused. One difference is that drug toxicity generally occurs over time, while drug overdose happens when too much of a substance is consumed at once. Drug toxicity is typically accidental, while drug overdose can be either accidental or intentional.

Why Drugs Can Be Toxic

Drug toxicity can occur as a result of the over-ingestion of medication, causing too much of the drug to be in a person’s system at once. This can happen if the dose taken exceeds the prescribed amount, or if the prescribed dosage is too high.

With certain medications, drug toxicity can also occur as an adverse drug reaction. In this case, the normal therapeutic dose of the drug can cause unintentional, harmful, and unwanted side effects.

In some cases, the threshold between an effective dose and a toxic dose is very narrow. A therapeutic dose for one person might be toxic to another person. Plus, drugs with a longer half-life can build up in a person’s bloodstream and increase over time, resulting in drug toxicity.

Additionally, factors such as age, kidney function, and hydration can affect how quickly your body can clear a medication from your system. This is why medications such as lithium require frequent blood testing to track the levels in the bloodstream.

It’s important to remember that even therapeutic doses of a medication can become toxic if the body’s ability to metabolize or eliminate the medication is impaired. People with liver or kidney issues are often particularly at risk.

Three factors determine the toxicity of a toxin or prescription drug. They are:

  • Chemical structure
  • How much the body can absorb
  • The body’s ability to detoxify and eliminate the substance

Symptoms of Drug Toxicity

How do you know if you or someone you know is experiencing drug toxicity effects? Drug toxicity symptoms can differ depending on the medication you are taking. In the case of lithium, for instance, mild symptoms of acute lithium toxicity (which is drug toxicity after taking the drug one time) can include:

  • Diarrhea
  • Dizziness
  • Nausea
  • Stomach pains
  • Vomiting
  • Weakness

More severe symptoms of acute lithium toxicity may appear in the form of:

  • Ataxia (poor muscle control, resulting in clumsy movements)
  • Coma
  • Hand tremors
  • Heart problems (in rare cases)
  • Muscle twitches
  • Nystagmus (involuntary jerking of the eyeball)
  • Seizures
  • Slurred speech

Chronic lithium toxicity—or drug toxicity resulting from a slow build-up over time—displays different symptoms, including slurred speech, tremors, and increased reflexes.

Tegretol (carbamazepine) is a drug often prescribed for epilepsy but also used to help treat mental health conditions such as schizophrenia and bipolar disorder. Some patients with carbamazepine toxicity have experienced symptoms including:

  • Blurred vision
  • Dizziness
  • Nystagmus
  • Trouble walking

In cases of severe carbamazepine toxicity, symptoms can include:

  • Altered levels of consciousness
  • Coma
  • Seizures

This is why it is important to read medication labels carefully. Also, ask your healthcare provider about the signs and symptoms of drug toxicity for any medication that you are taking, since they can differ from drug to drug.

How It’s Diagnosed

Acute drug toxicity is more easily diagnosed as the symptoms follow the taking of the medication just one time.

Blood tests can also screen for levels of the medication in the bloodstream, showing whether these levels are too high.

Chronic drug toxicity, or drug toxicity that occurs due to long-term build-up, is harder to identify. Symptoms of toxicity can be initially subtle, like nausea and fatigue. This can sometimes make detecting toxicity tricky until it becomes more serious.

Stopping the medication, then “re-challenging” it later, is one method of testing whether the symptoms are caused by the medicine. This method can be problematic, however, if the medication is essential and doesn’t have an equivalent substitute.

What Can You Do About It?

There are several ways drug toxicity may be treated. If the toxicity results from an acute overdose, a person may undergo stomach pumping to remove drugs that have not yet been absorbed. 

Activated charcoal is another drug toxicity treatment option. It can be used to bind the drug, preventing it from being absorbed into the blood. (If this approach is used, the drug is eliminated from the body through stool). Other medications may also be given as an antidote for drug toxicity.

If you believe that you or someone else has symptoms of drug toxicity or overdose, contact medical services immediately. Quick treatment can result in fewer complications.

Reducing the Risk

The best way to reduce the risk of drug toxicity is to:

  • Always take your medication as prescribed
  • Tell your doctor about any other medications or supplements you are taking
  • Inform your doctor immediately if you begin to experience symptoms of drug toxicity

Avoid crushing or altering medications unless you’ve already discussed this with your doctor. Changing how you take your medication can unintentionally increase their toxicity, particularly if it is a time-released formula.

Certain drug interactions can also affect drug toxicity. For example, combining over-the-counter medications with prescription medications can affect how each drug is metabolized. Even though these medications are safe on their own, interactions can lead to toxicity.

Being aware of your own risk can also help. Older adults often have a higher risk of experiencing drug toxicity because they metabolize substances more slowly and tend to take more medications in general.

Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Dasgupta M. Neurotoxicity, immunotoxicity and drug toxicity – a review. Adv Clin Toxicol. 2018;3(1):000S1-001.

  2. Silakari O, Singh PK. ADMET tools: Prediction and assessment of chemical ADMET properties of NCEs. In: Concepts and Experimental Protocols of Modelling and Informatics in Drug Design. Elsevier; 2021:299-320. doi:10.1016/B978-0-12-820546-4.00014-3

  3. Schulz M, Schmoldt A, Andresen-Streichert H, Iwersen-Bergmann S. Revisited: Therapeutic and toxic blood concentrations of more than 1100 drugs and other xenobioticsCrit Care. 2020;24(1):195. doi:10.1186/s13054-020-02915-5

  4. Department of Labor and Industries. Understanding toxic substances. Purdue University.

  5. U.S. National Library of Medicine. Lithium carbonate capsule.

  6. Wirfs L, Whitworth K, Kellar J. Nystagmus associated with carbamazepine toxicity. Clin Pract Cases Emerg Med. 2017;1(4):441-442. doi:10.5811/cpcem.2017.6.34772

By Nancy Schimelpfening

Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be.  


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Elizabeth Scott, MS

Rumination Signs and How to Stop the Cycle

We all experience negative thoughts sometimes, but when we spend *too* much time dwelling on them, it can create distress and even contribute to mental health problems. Rumination involves repetitive and passive thoughts focused on the causes and effects of a person’s distress. The problem is that these negative thoughts don’t lead to solutions.

We often slip into this type of thinking when we’re faced with a problem we want to solve. They tend to creep in when we’re stressed or dealing with something overwhelming. Instead of inspiring us to engage in active coping mechanisms or problem-solving strategies to relieve distress and improve mood, we often get stuck in a negative, self-sabotaging loop.

While it seems like solving the problem will resolve the stress, rumination does not lead to any solutions. Examining memories, situations, and feelings can be an essential part of processing our experiences, but processing and ruminating are different things, and learning how to distinguish between the two can be important for your mental well-being.

Signs of Rumination

What does rumination look like, and how is it different from productive emotional processing? Rumination and emotional processing both focus on problems and usually on emotions surrounding these problems.

  • Rumination, however, tends to be more negative. It often includes thought patterns that involve pessimism and cognitive distortions, and focuses mainly on the negative aspects of a situation.
  • Emotional processing, by contrast, may start this way, but leads to acceptance and release of negative emotions, while rumination keeps you “stuck.”

As a general rule, the following can be indicators that you may have fallen into the trap of rumination:

  • Focusing on a problem for more than a few idle minutes
  • Feeling worse than you started out feeling
  • No movement toward accepting and moving on
  • No closer to a viable solution

Likewise, with a conversation with a friend, if you both end up feeling worse afterward, you’ve likely just engaged in co-rumination.

How Rumination Works

Most people don’t set out to ruminate over their problems. Most of us want to be happy and want to focus on thoughts that make us happy. The problem occurs when something frustrating, threatening, or insulting happens to us—something that is difficult to accept—and we can’t let it go.

We may be trying to make sense of it in our minds. Or we might be attempting to learn from it. In other cases, we may be seeking validation that this should not have happened. Whatever the reason, though, we can’t stop thinking about it, and when we think about it, we become upset.

The unproductively negative focus it takes is the defining aspect of rumination that differentiates it from regular problem-solving. Rumination may involve going over the details of a situation in one’s head or talking to friends about it.

Rumination vs. Emotional Processing

As you look at the difference between rumination and emotional processing, you might have several concerns:

  • If we don’t think about our problems, how can we hope to solve them or learn from the process?
  • Should we focus only on the positive?
  • Don’t we sacrifice growth and solutions if we don’t focus on unpleasant situations from time to time?

These are important questions because knowing the happy midpoint between ignoring problems and engaging in rumination can save us a lot of stress.

Rumination

  • Often leads to self-blame, guilt, or shame

  • Does not produce solutions or insights

  • Can lead to blaming others

  • Focuses on the negative

Emotional Processing

  • Leads to feelings of acceptance

  • Produces solutions and insights

  • Allows people to put situations in perspective

  • Helps people look for the positive

Rumination involves negative thought patterns that are immersive or repetitive. Many people slip into rumination when trying to process their emotions, but they become “stuck” in negative patterns of replaying past hurts without moving toward solutions or feelings of resolution.

What distinguishes rumination or “dwelling on problems” from productive emotional processing or searching for solutions is that rumination doesn’t generate new ways of thinking, new behaviors, or new possibilities. Ruminative thinkers repeatedly go over the same information without change and stay in a negative mindset.

Rumination can even be “contagious” in a sense. Two people can engage in “co-rumination” and keep a negative situation alive between them with little movement toward the positive.

What Causes Rumination?

It is normal to ruminate on things from time to time, particularly if you are thinking about a stressful or upsetting experience. People may ruminate because they believe they can solve a problem or gain insight by thinking about it repeatedly. Having a history of trauma or dealing with stressful situations in the present can also contribute to rumination.

Some factors that might cause rumination:

  • Certain personality traits such as perfectionism or neuroticism
  • Stressful events such as job loss or a relationship break up
  • Poor self-esteem
  • Stressing about something you fear
  • Traumatic events
  • Worrying about upcoming events like a work presentation or exam
  • Worrying about a health condition

Negative Impacts

Rumination is connected to a variety of mental health conditions, creating a relationship where each can influence the other. While these conditions can lead to rumination, those persistent thoughts can also make the symptoms of these conditions even more challenging to handle. 

Mental conditions that can cause rumination or be worsened by it include:

  • Anxiety is often marked by worrying or ruminating over specific fears or anticipated situations. Research has shown that rumination is a risk factor for anxiety.
  • Depression can cause people to ruminate over negative thoughts. Numerous studies have linked rumination as a significant risk factor for the onset of depression. Research suggests that rumination can be a maladaptive way of responding to a depressed mood, leading to more feelings of depression.
  • Eating disorders can cause people to ruminate about food, dieting, and exercising. Research has found that people who exhibit eating disorder psychopathology are more likely to experience ruminating thoughts, and such thoughts tend to decrease mood and cause more negative body-related thoughts.
  • Obsessive-compulsive disorder (OCD) causes intrusive, obsessive thoughts that may lead to compulsive behaviors to relieve distress. One study found that rumination plays a role in maintaining OCD symptoms that can also contribute to depressed mood.
  • Post-traumatic stress disorder (PTSD) often involves ruminating about traumatic memories. Researchers believe that rumination may be an intentional way to understand and process the trauma, although the results are ultimately ineffective.

How to Stop Ruminating

Rumination can be difficult to give up, especially if you don’t recognize it as rumination or don’t know how to stop. Letting go of stress and anger can help with ruminative thinking.

Some strategies that might help you learn to let go of repetitive thoughts include:

  • Try meditation: Meditation can help relieve feelings of stress and redirect thoughts toward less negative patterns.
  • Distract yourself: When you ruminate on negative thoughts, break out of the pattern by doing something to distract yourself from your thoughts. Try doing a puzzle, reading a book, calling a friend, or watching a movie.
  • Challenge your thoughts: Remind yourself that thoughts are not facts. Instead of accepting a negative thought as reality, actively challenge it and look for alternative explanations.
  • Engage in exercise: Physical activity can be a great way to distract from negative thoughts, but research has also found that it can significantly reduce rumination in people with a mental health diagnosis.
  • Go outside: Research has also found that spending time in nature can significantly reduce rumination. Try combining exercise and nature exposure by walking in a park or natural setting.
  • Cull your social media feeds: It is also important to avoid or minimize contact with things that trigger rumination. For example, if scrolling through your social media feeds leaves you with negative thoughts about your life, relationships, or appearance, consider unfollowing accounts that lead to these negative thoughts and feelings.
  • Cultivate social support: Having people you can lean on is important in times of stress. Your social connections can be an essential source of support and help distract you from negative thoughts.

If self-help strategies are not providing enough relief, consider talking to a mental health professional. Therapy approaches such as cognitive-behavioral therapy (CBT) can help you change the negative thought patterns associated with rumination and develop new ways of coping.

Press Play for Advice On Managing Rumination

This episode of The Verywell Mind Podcast shares strategies to help you manage your overthinking, featuring bestselling author Jon Acuff.

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Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Joubert AE, Moulds ML, Werner-Seidler A, Sharrock M, Popovic B, Newby JM. Understanding the experience of rumination and worry: A descriptive qualitative survey studyBr J Clin Psychol. 2022;61(4):929-946. doi:10.1111/bjc.12367

  2. Ehring T. Thinking too much: Rumination and psychopathology. World Psychiatry. 2021;20(3):441-442. doi:10.1002/wps.20910

  3. American Psychological Association. Probing the depression-rumination cycle.

  4. Joubert AE, Moulds ML, Werner-Seidler A, Sharrock M, Popovic B, Newby JM. Understanding the experience of rumination and worry: A descriptive qualitative survey studyBr J Clin Psychol. 2022;61(4):929-946. doi:10.1111/bjc.12367

  5. Smith KE, Mason TB, Lavender JM. Rumination and eating disorder psychopathology: A meta-analysis. Clin Psychol Rev. 2018;61:9-23. doi:10.1016/j.cpr.2018.03.004

  6. Wahl K, van den Hout M, Heinzel CV, et al. Rumination about obsessive symptoms and mood maintains obsessive-compulsive symptoms and depressed mood: An experimental study. Journal of Abnormal Psychology. 2021;130(5):435-442. doi:10.1037/abn0000677

  7. Xu W, Feng C, Tang W, Yang Y. Rumination, posttraumatic stress disorder symptoms, and posttraumatic growth among Wenchuan earthquake adult survivors: A developmental perspective. Front Public Health. 2022;9:764127. doi:10.3389/fpubh.2021.764127

  8. Brand S, Colledge F, Ludyga S, Emmenegger R, Kalak N, Sadeghi Bahmani D, Holsboer-Trachsler E, Pühse U, Gerber M. Acute bouts of exercising improved mood, rumination and social interaction in inpatients with mental disorders. Front Psychol. 2018;9:249. doi:10.3389/fpsyg.2018.0024

  9. Bratman GN, Hamilton JP, Hahn KS, Daily GC, Gross JJ. Nature experience reduces rumination and subgenual prefrontal cortex activation. Proc Natl Acad Sci USA. 2015;112(28):8567-8572. doi:10.1073/pnas.1510459112

Elizabeth Scott, MS

By Elizabeth Scott, PhD

Elizabeth Scott, PhD is an author, workshop leader, educator, and award-winning blogger on stress management, positive psychology, relationships, and emotional wellbeing.


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How Cancer Affects Your Mental Health In Ways You May Not Expect


The beginning of August can signal the final days of summer, college move-in preparations, and squeezing in a final family vacation. But on August 1, 2023, it signaled something altogether different for Mary Beth Brault. Her life shifted. It was the day that she was diagnosed with PH+ B-cell acute lymphoblastic leukemia.

For the then-55-year-old, it was “a long, complex name for an aggressive blood cancer that hit like a freight train,” she says. “It shattered everything and rocked the foundation of our world. At the beginning of July, I was working, traveling, and going to concerts with my kids. By July 31, I could barely walk into the emergency room. Overnight, my whole life changed. But the worst moment—far and away—was telling my children. That broke me.”

According to the National Cancer Institute, approximately two million people will be diagnosed with cancer in 2025. Most people know that the disease takes a physical toll on the body, including fatigue, pain, nausea, and vomiting. But they may not factor in the mental and emotional toll of the disease.

Overnight, my whole life changed

“Being diagnosed with cancer can bring on a wide range of strong emotions in the period after diagnosis. Immediate reactions can vary – but many people feel shocked or numb, finding it hard to believe or fully process the news,” explains Michael A. Hoyt, PhD, professor and chair of Population Health & Disease Prevention of UC Irvine’s Joe C. Wen School of Population & Public Health.

From anger to anxiety, guilt to determination, a cancer diagnosis takes a toll on the person with the disease, as well as their family and friends.

Initial Reactions and Emotions

Brian Koffman, MDCM, is the co-founder, chief medical officer, and EVP of CLL Society Inc., an organization that addresses the needs of leukemia and lymphoma patients. His connection is intensely personal.

“I was diagnosed with chronic lymphocytic leukemia (CLL) in 2005,” he says. “My cancer diagnosis was a complete shock and raised disbelief. I was feeling well and was surprised when the leukemia was discovered on routine blood work,” he notes. “It was a gut punch.”

His initial reaction mirrors that of many other cancer patients. And as the reality of the diagnosis settles in, it can lead to feeling like there is a complete loss of autonomy.

“Cancer is a thief, upending your sense of safety in your own body and your plans and hopes for the future. Depending on the type of treatment you need, you may have to give up the routine and activities you built your life around. It can feel like you’ve lost control over your life as you pivot your attention to battling cancer and coping with the uncertainty it brings,” says Hannah Holmes, PhD, clinical health psychologist at Holmes Psychology.

Forging an unknown path can also lead to unexpected emotions. These include:

  • Stress and anxiety. “Fear and anxiety are also very common — people often worry about what will happen next, how they’ll get through treatment, and what it means for their future,” says
    Dr. Hoyt.
  • Depression and sadness. One in four cancer patients struggle with depression. Unfortunately,
    only 5% of those struggling see a mental health professional, according to the National
    Cancer Institute.
  • Anger and denial. “Some people feel angry — at the situation, the healthcare system, or just at the unfairness of it all. Others may go into denial, telling themselves it can’t be true, as a way to cope with the overwhelming news,” Dr. Hoyt notes.
  • Guilt. People can experience guilt if they feel like the cancer is their fault, or they feel bad about burdening their family and friends.

Dealing With Misconceptions

You may also find yourself dealing with common misconceptions others have about walking through the cancer journey, such as:

  • You shouldn’t be secluded. “The biggest misconception in my case was isolation—and why it’s necessary,” states Brault. “Once chemo started and my immune system was gone, I was essentially on lockdown. So was my husband. One random virus could [have] killed me.”
  • Cancer patients need additional advice. “Another common issue: unsolicited advice. ‘Drink green juice.’ ‘Avoid sugar.’ ‘Try this herb.’ Let’s be honest — by the time you’re diagnosed, the ship has sailed. And I hate to state the obvious, but the chemo they are dumping into my body is exponentially more toxic than any cookie. People mean well, but it’s exhausting,” Brault says.
  • All cancers behave the same way. “[It’s] a common misconception that a particular cancer diagnosis is predictable in its behavior and prognosis. There are always ‘outliers’ who beat the odds and live far beyond their ‘predicted’ life expectancy,” says Dr. Koffman.

Finding Hope and Joy

While research doesn’t necessarily show there is a correlation between a positive attitude and cancer treatment outcomes, for some, it can make a difference in the journey.

“What I love about the focus on hope involves taking a step back and asking ourselves what hope really is… and the way I have considered hope in my own work is to think of hope as a possessing the belief, skills, and actions to identify and pursue the things you value most in life,” says Dr. Hoyt.

Hope can help shift focus – from the difficulty and pain of cancer to things in life that bring joy or pleasure. And research does show that positive thinking builds resiliency and combats the stress’ inflammatory process. And joy can be found in regular, everyday activities, or things that give you a new sense of purpose.

Coping Mechanisms and Support Systems

Whether it’s a group of people walking through the same journey, friends, or a spouse, a support system is a critical part of your mental and emotional health when dealing with cancer. In addition to having people who care about you and help you, it’s beneficial to have other methods of coping.

Ideas include:

  • Seeking out professional counseling. A mental health professional who is trained to help you navigate the emotions that come with a cancer diagnosis can offer critical support.
  • Journaling. Getting your feelings out on paper can be a cathartic experience.
  • Establish boundaries. “Saying no to energy-drainers and the people that never gave support [helps to protect] my peace,” Brault notes.
  • Take part in hobbies you enjoy.
  • Be patient with yourself. Learn to rest when you need it.
  • Check out cancer support groups: Finding like-minded people is a great way to relate through lived experience, get guidance, and have a place to talk with others who understand the process.
  • Prioritize rest. it is more important than ever to take care of yourself.
  • Find ways to reduce stress. Techniques that involve nervous system regulation and mindfulness may be helpful.
  • Practice vulnerability. Learn to express emotions with people who know how to listen without attempting to ‘fix’ you. Bottling up emotions can increase feelings of stress, anxiety, and depression.

People think they know what they will do when challenges strike. But often, you don’t truly know until you are experiencing it. Give yourself grace as you walk through your cancer journey, and care for yourself physically, emotionally, and mentally.


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